Not quite sure how one would go about this, but I'd love to see someone try.
I guess you would have to grim'n'dark up that kind of a setting, also things like raging against the machine and computer hacking might be different. Perhaps something involving ham radios (since it's Buck Rogers, afterall). I'd love to see some rule such as that found in Buck Rogers or Flash Gordon in which someone can simply roll down their window to shoot at a space ship with their pistol and no space suit whatsoever.
Just a thought.